KLK9 and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		KLK9	PTPRJ
Description		kallikrein related peptidase 9	protein tyrosine phosphatase receptor type J
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Proteolysis	Protein Dephosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways			Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Offspring birth weight ( 31043758) Sleep duration (short sleep) ( 30846698)
Interacting Genes		11 interacting genes: APP BAG4 BRMS1 CASP8 CCND1 CHEK2 ESR1 ESR2 PAX2 PTPRJ TGFB1	20 interacting genes: BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 HOXC6 IL2RG JUP KLK7 KLK9 LAT LYPD3 MET NOP2 PDGFRB PLCG1 PRDM14 SDCBP
Entrez ID		284366	5795
HPRD ID		05692	02955
Ensembl ID		ENSG00000213022	ENSG00000149177
Uniprot IDs		Q2XQG6 Q9UKQ9	Q12913 Q9NPR5
PDB IDs			2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?
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