GNAO1 and SCN8A

Number of citations of the paper that reports this interaction (PubMedID 10066808)
3

Data Source:
HPRD (in vivo, in vitro)

		GNAO1	SCN8A
Description		G protein subunit alpha o1	sodium voltage-gated channel alpha subunit 8
Image			No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity Protein Binding ATP Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Valproic Acid Tetrodotoxin Brivaracetam
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	6 interacting genes: ADAM9 FGF13 FGF14 GNAO1 MAPK14 OS9
Entrez ID		2775	6334
HPRD ID		00757	09006
Ensembl ID		ENSG00000087258	ENSG00000196876
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q6B4S4 Q9UQD0
PDB IDs		6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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