GNA12 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 8290554)
69

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNA12	TBXA2R
Description		G protein subunit alpha 12	thromboxane A2 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane	Acrosomal Vesicle Cell Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	In Utero Embryonic Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug Embryonic Digit Morphogenesis	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs			Ridogrel Seratrodast
Diseases
GWAS		Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 27863252) Plateletcrit ( 27863252) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		29 interacting genes: ACTB AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR	22 interacting genes: GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 NME2 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L YWHAZ
Entrez ID		2768	6915
HPRD ID		05093	01768
Ensembl ID		ENSG00000146535	ENSG00000006638
Uniprot IDs		E9PC54 Q03113 Q6ZQV4	P21731 Q05C92 Q0VAB0
PDB IDs			1LBN
Enriched GO Terms of Interacting Partners?
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