GLRX and GOT2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		GLRX	GOT2
Description		glutaredoxin	glutamic-oxaloacetic transaminase 2
Image
GO Annotations	Cellular Component	Cell Nucleus Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface T-tubule Protein-containing Complex Perikaryon Extracellular Exosome
	Molecular Function	Electron Transfer Activity Glutathione Disulfide Oxidoreductase Activity Protein N-terminus Binding Glutathione Oxidoreductase Activity	RNA Binding L-aspartate:2-oxoglutarate Aminotransferase Activity Phospholipid Binding Kynurenine-oxoglutarate Transaminase Activity Amino Acid Binding Enzyme Binding Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Nucleobase-containing Small Molecule Interconversion Electron Transport Chain Cell Redox Homeostasis Positive Regulation Of Membrane Potential Protein Deglutathionylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Female Pregnancy Lactation Cellular Amino Acid Biosynthetic Process Response To Muscle Activity Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Response To Insulin Response To Morphine Response To Ethanol Glyoxylate Metabolic Process L-kynurenine Metabolic Process
Pathways		Interconversion of nucleotide di- and triphosphates	Degradation of cysteine and homocysteine Glyoxylate metabolism and glycine degradation Gluconeogenesis Aspartate and asparagine metabolism Glutamate and glutamine metabolism
Drugs		Glutathione	Pyridoxal Phosphate L-Aspartic Acid Glutamic Acid 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Metabolite levels ( 23823483) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Aortic root size ( 21223598) Aspartate aminotransferase levels ( 29403010) Automobile speeding propensity ( 30643258) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Impulsivity (attentional) ( 30718321) Metabolite levels ( 23823483) QT interval ( 19305408) Urinary metabolite levels in chronic kidney disease ( 31959995) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		7 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1	11 interacting genes: APCS CCL21 CSNK2A2 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		2745	2806
HPRD ID		02707	00684
Ensembl ID		ENSG00000173221	ENSG00000125166
Uniprot IDs		A0A024RAM2 P35754	P00505
PDB IDs		1B4Q 1JHB 4RQR	5AX8
Enriched GO Terms of Interacting Partners?
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