DESI1 and FGF7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		DESI1	FGF7
Description		desumoylating isopeptidase 1	fibroblast growth factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Golgi Apparatus
	Molecular Function	Peptidase Activity Identical Protein Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Proteolysis	MAPK Cascade Signal Transduction Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways			PI3K Cascade PIP3 activates AKT signaling FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Neuroticism ( 29255261)	Blood protein levels ( 30072576 29875488) Lung adenocarcinoma ( 28604730) Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Interacting Genes		5 interacting genes: FGF7 RBX1 UBC XPO1 ZBTB46	14 interacting genes: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 PTX3 UBQLN1
Entrez ID		27351	2252
HPRD ID		18590	01022
Ensembl ID		ENSG00000100418	ENSG00000140285
Uniprot IDs		Q6ICB0	P21781
PDB IDs		3EBQ
Enriched GO Terms of Interacting Partners?
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