PCSK1N and PCSK1

Number of citations of the paper that reports this interaction (PubMedID 11435430)
17

Data Source:
HPRD (in vitro)

		PCSK1N	PCSK1
Description		proprotein convertase subtilisin/kexin type 1 inhibitor	proprotein convertase subtilisin/kexin type 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Trans-Golgi Network Secretory Granule	Extracellular Space Membrane Transport Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding	Serine-type Endopeptidase Activity Identical Protein Binding
	Biological Process	Response To Dietary Excess Neuropeptide Signaling Pathway Response To Cold Negative Regulation Of Endopeptidase Activity Peptide Hormone Processing	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Peptide Biosynthetic Process
Pathways			Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs			Insulin Human Insulin Pork
Diseases
GWAS		Type 2 diabetes ( 30718926)	Blood protein levels ( 30072576 29875488) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 24861553 28892062 25673413 29273807) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Glycemic traits (pregnancy) ( 23903356) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Waist circumference ( 23966867)
Interacting Genes		2 interacting genes: PCSK1 RAD51	4 interacting genes: IAPP PCSK1N PMCH REN
Entrez ID		27344	5122
HPRD ID		02320	01201
Ensembl ID		ENSG00000102109	ENSG00000175426
Uniprot IDs		Q9UHG2	P29120
PDB IDs
Enriched GO Terms of Interacting Partners?
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