SRPX2 and ADAMTS4

Number of citations of the paper that reports this interaction (PubMedID 18718938)
25

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SRPX2	ADAMTS4
Description		sushi repeat containing protein X-linked 2	ADAM metallopeptidase with thrombospondin type 1 motif 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Collagen-containing Extracellular Matrix Synaptic Membrane	Extracellular Region Extracellular Space Nuclear Speck Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Metal Ion Binding
	Biological Process	Angiogenesis Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cell-cell Adhesion	Skeletal System Development Proteolysis Extracellular Matrix Disassembly
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS			Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31361310 27182965 31619474) Family history of Alzheimer's disease ( 30617256) Monocyte percentage of white cells ( 27863252)
Interacting Genes		3 interacting genes: ADAMTS4 CTSB PLAUR	11 interacting genes: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		27286	9507
HPRD ID		06726	04853
Ensembl ID		ENSG00000102359	ENSG00000158859
Uniprot IDs		O60687	O75173
PDB IDs			2RJP 3B2Z 4WK7 4WKE 4WKI
Enriched GO Terms of Interacting Partners?
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