SRPX2 and PLAUR

Number of citations of the paper that reports this interaction (PubMedID 18718938)
25

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SRPX2	PLAUR
Description		sushi repeat containing protein X-linked 2	plasminogen activator, urokinase receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Collagen-containing Extracellular Matrix Synaptic Membrane	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Specific Granule Membrane Invadopodium Membrane
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity
	Biological Process	Angiogenesis Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cell-cell Adhesion	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways			Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase WX-UK1
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS			Blood protein levels ( 30072576 29875488) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		3 interacting genes: ADAMTS4 CTSB PLAUR	20 interacting genes: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		27286	5329
HPRD ID		06726	01421
Ensembl ID		ENSG00000102359	ENSG00000011422
Uniprot IDs		O60687	M0R1I2 Q03405
PDB IDs			1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI
Enriched GO Terms of Interacting Partners?
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