NDOR1 and CYCS

Number of citations of the paper that reports this interaction (PubMedID 10625700)
22

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NDOR1	CYCS
Description		NADPH dependent diflavin oxidoreductase 1	cytochrome c, somatic
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Protein Phosphatase Type 2A Complex Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Respiratory Chain
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Flavin Adenine Dinucleotide Binding NADP Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Heme Binding Electron Transporter, Transferring Electrons From CoQH2-cytochrome C Reductase Complex And Cytochrome C Oxidase Complex Activity Metal Ion Binding
	Biological Process	Cell Death Iron-sulfur Cluster Assembly Cellular Response To Menadione Oxidation-reduction Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Mitochondrial Electron Transport, Cytochrome C To Oxygen Protein Dephosphorylation Apoptotic Process Mitochondrion Organization Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Cellular Response To Oxidative Stress Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Respiration
Pathways		Cytosolic iron-sulfur cluster assembly	Release of apoptotic factors from the mitochondria Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Respiratory electron transport Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Minocycline Protoporphyrin Ix Containing Co Heme C Imidazole Protoporphyrin Ix Containing Zn N-Trimethyllysine Zinc Substituted Heme C
Diseases			Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Alzheimer's disease (cognitive decline) ( 23535033) High density lipoprotein cholesterol levels ( 30498476) Systemic lupus erythematosus ( 19838195)
Interacting Genes		8 interacting genes: CCDC33 CYCS DLG4 EFHC2 MTUS2 PMPCA TCF4 TCHP	21 interacting genes: AGTPBP1 APAF1 BCL2 BCL2L1 CASP9 COX4I2 CUL9 CYB5A CYB5R1 CYB5R3 CYC1 FDX1 HSPA8 HSPB1 KRT40 NDOR1 RNF7 SAFB SNCA UQCRC1 VDAC2
Entrez ID		27158	54205
HPRD ID		10444	00479
Ensembl ID		ENSG00000188566	ENSG00000172115
Uniprot IDs		Q9UHB4	G4XXL9 P99999
PDB IDs		4H2D	1J3S 2N3Y 2N9I 2N9J 3NWV 3ZCF 3ZOO 5EXQ 5O10 5TY3 6DUJ 6ECJ
Enriched GO Terms of Interacting Partners?
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