SNX5 and SNX2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, two hybrid)

		SNX5	SNX2
Description		sorting nexin 5	sorting nexin 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Endosome Cytosol Brush Border Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Protein Heterodimerization Activity Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Pinocytosis Epidermal Growth Factor Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Renal Sodium Excretion Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway	Intracellular Protein Transport Endocytosis Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis
Pathways		Golgi Associated Vesicle Biogenesis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308)
Interacting Genes		15 interacting genes: APPBP2 AQP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESD MIB1 PFDN1 PRKRA SNX2	20 interacting genes: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202
Entrez ID		27131	6643
HPRD ID		10439	09332
Ensembl ID		ENSG00000089006	ENSG00000205302
Uniprot IDs		Q6P5V6 Q9Y5X3	O60749
PDB IDs		1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z
Enriched GO Terms of Interacting Partners?
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