PABPC1 and ATXN2

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical, pull down)
HPRD (two hybrid, in vivo)

		PABPC1	ATXN2
Description		poly(A) binding protein cytoplasmic 1	ataxin 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Polysome Cytoplasmic Stress Granule Membrane Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	RNA Binding Epidermal Growth Factor Receptor Binding Protein Binding Protein C-terminus Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translational Initiation Gene Silencing By RNA Regulation Of MRNA Stability Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Negative Regulation Of Receptor Internalization Regulation Of Translation Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Metabolic Process Cytoplasmic MRNA Processing Body Assembly Stress Granule Assembly RNA Transport
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Body mass index ( 26426971)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Alopecia areata ( 25608926) Asthma ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Beta-2 microglubulin plasma levels ( 23417110) Blood osmolality (transformed sodium) ( 28360221) Blood pressure ( 21909110) Body mass index ( 26426971) Celiac disease ( 22057235 18311140) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778 30104761) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 27736895 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Gastroesophageal reflux disease ( 31527586) Glaucoma (primary open-angle) ( 26752265) Glomerular filtration rate (cystatin C) ( 28452372) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) Heart failure ( 31919418) Hematocrit ( 19862010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 30054594) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) LDL cholesterol ( 30275531) Left ventricle diastolic internal dimension ( 28394258) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 27863252) Monocyte count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 24026423 29403010 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Reaction time ( 29844566) Red blood cell traits ( 23222517) Reticulocyte fraction of red cells ( 27863252) Retinal vascular caliber ( 21060863) Sarcoidosis ( 26051272) Serum total protein level ( 29403010) SjÃ¶gren's syndrome ( 24097067) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Total cholesterol levels ( 30275531) Urate levels ( 31578528 23263486) Vitiligo ( 27723757)
Interacting Genes		52 interacting genes: ANAPC5 APBB1 ATP6V1C1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DCAF13 EIF4B EIF4G1 EIF4G3 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LRP12 LRP1B MAPKAPK2 MET NDRG1 NFX1 ODF1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCED1A PCSK7 PIN1 PITPNA PRMT6 PXN RACK1 RBM4 RIMS2 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	20 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CHGB GFI1B GOLGA6L5P IDH3B IMPDH2 KIFBP LCP1 NCOA4 PABPC1 PLS3 RBFOX1 SH3GL2 SH3GL3 TDRD7 ZNRD1
Entrez ID		26986	6311
HPRD ID		05247	03307
Ensembl ID		ENSG00000070756	ENSG00000204842
Uniprot IDs		A0A024R9C1 P11940	F8VQP2 Q2M2R5 Q99700
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS	3KTR
Enriched GO Terms of Interacting Partners?
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