PABPC1 and HNRNPD

Number of citations of the paper that reports this interaction (PubMedID 11051545)
113

Data Source:
HPRD (in vivo)

		PABPC1	HNRNPD
Description		poly(A) binding protein cytoplasmic 1	heterogeneous nuclear ribonucleoprotein D
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Synapse Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	AT DNA Binding Chromatin Binding RNA Binding Protein Binding Transcription Factor Binding MRNA 3'-UTR AU-rich Region Binding Telomeric DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translational Initiation Gene Silencing By RNA Regulation Of MRNA Stability Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	MRNA Splicing, Via Spliceosome Liver Development Regulation Of Transcription, DNA-templated RNA Processing RNA Catabolic Process RNA Metabolic Process Cerebellum Development Regulation Of Telomere Maintenance Regulation Of Circadian Rhythm Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Regulation Of RNA Metabolic Process Response To Calcium Ion Response To Electrical Stimulus 3'-UTR-mediated MRNA Destabilization Cellular Response To Amino Acid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Nitric Oxide Circadian Regulation Of Translation Response To Rapamycin Positive Regulation Of Telomere Capping Response To Sodium Phosphate Cellular Response To Putrescine Positive Regulation Of Telomerase RNA Reverse Transcriptase Activity Hepatocyte Dedifferentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Artenimol
Diseases
GWAS		Body mass index ( 26426971)	Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		52 interacting genes: ANAPC5 APBB1 ATP6V1C1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DCAF13 EIF4B EIF4G1 EIF4G3 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LRP12 LRP1B MAPKAPK2 MET NDRG1 NFX1 ODF1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCED1A PCSK7 PIN1 PITPNA PRMT6 PXN RACK1 RBM4 RIMS2 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	88 interacting genes: ABCC10 ACTB ADGRE5 ARF4 B3GAT3 BCL2 BET1L BRCA1 C1QBP CAPN1 CD81 CINP COG7 COL18A1 CSDE1 CTSB CUTA DGCR2 DHX30 DMAC1 EEF2 ERG ESR1 EXOSC4 FBXL15 FLNA GSK3B GTF3C3 GTSE1 GUK1 HBZ HDAC1 HIRA HMGA1 HNRNPF HNRNPH3 HNRNPK HSPA4 HSPB1 HSPB2 IGF2BP2 IL7R IMMP2L IMMT ING4 LDHA LSM5 MAP2K1 MAPK6 MEOX2 MPP1 MTA2 NTMT1 P4HB PABPC1 PCBP1 PCBP2 PCSK7 PDLIM7 PEX10 PPOX PRDX3 PRKACA PTBP2 PYCR1 RALY RPSA SAFB SDF2 SEPTIN9 SF3B4 SFN SHISA5 SLC27A5 SLC3A2 SNAPC4 SNRPC SREK1 SUMO4 SYNCRIP TNPO1 TRN-GTT2-7 TSEN34 UBE2I UQCRC1 VEGFA VHL YBX1
Entrez ID		26986	3184
HPRD ID		05247	03206
Ensembl ID		ENSG00000070756	ENSG00000138668
Uniprot IDs		A0A024R9C1 P11940	A0A024RDB4 A0A024RDF4 A1LU37 Q14103
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS	1HD0 1HD1 1IQT 1WTB 1X0F 2Z5N 5IM0
Enriched GO Terms of Interacting Partners?
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