GBP1 and FNTB

Number of citations of the paper that reports this interaction (PubMedID 10676968)
95

Data Source:
HPRD (in vitro)

		GBP1	FNTB
Description		guanylate binding protein 1	farnesyltransferase, CAAX box, beta
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Vesicle Membrane Actin Cytoskeleton Cytoplasmic Vesicle	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Actin Binding GTPase Activity Protein Binding GTP Binding GDP Binding Enzyme Binding Cytokine Binding Spectrin Binding Identical Protein Binding Protein Homodimerization Activity Hsp90 Protein Binding	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Calcium-mediated Signaling Negative Regulation Of T Cell Receptor Signaling Pathway Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Protein Localization To Vacuole Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Interleukin-2 Secretion Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Plasma Membrane	Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway
Pathways		Interferon gamma signaling	Inactivation, recovery and regulation of the phototransduction cascade
Drugs			AZD3409 Tipifarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Remission after SSRI treatment in MDD or openness ( 29559929)	Blood trace element (Zn levels) ( 23720494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)
Interacting Genes		3 interacting genes: FNTA FNTB PTBP2	9 interacting genes: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2
Entrez ID		2633	2342
HPRD ID		02681	00608
Ensembl ID		ENSG00000117228	ENSG00000257365
Uniprot IDs		P32455	A0A384MEJ5 P49356
PDB IDs		1DG3 1F5N 2B8W 2B92 2BC9 2D4H 6K1Z 6K2D	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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