FNTB and CENPF

Number of citations of the paper that reports this interaction (PubMedID 10852915)
64

Data Source:
HPRD (in vitro)

		FNTB	CENPF
Description		farnesyltransferase, CAAX box, beta	centromere protein F
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Cell Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber
	Molecular Function	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding	Chromatin Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Complex Binding
	Biological Process	Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Muscle Organ Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		AZD3409 Tipifarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE 4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23222517)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360)
Interacting Genes		9 interacting genes: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2	16 interacting genes: BRAP CENPE CHMP2B FNTA FNTB HSD11B1 IRF6 KLHL41 NDEL1 NUP133 PLOD2 SLC30A1 SLC4A1AP SNAP25 SVIL TOP3B
Entrez ID		2342	1063
HPRD ID		00608	02582
Ensembl ID		ENSG00000257365	ENSG00000117724
Uniprot IDs		A0A384MEJ5 P49356	P49454
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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