TINF2 and TBL1X

Number of citations of the paper that reports this interaction (PubMedID 21044950)
41

Data Source:
BioGRID (two hybrid)

		TINF2	TBL1X
Description		TERF1 interacting nuclear factor 2	transducin beta like 1 X-linked
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Transcriptional Repressor Complex Mitotic Spindle
	Molecular Function	DNA Binding Protein Binding Telomeric DNA Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Protein ADP-ribosylation Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases		Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Leukocyte telomere length ( 31171785) Platelet count ( 29403010)	Prostate cancer ( 23535732)
Interacting Genes		89 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790	28 interacting genes: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I
Entrez ID		26277	6907
HPRD ID		16056	02183
Ensembl ID		ENSG00000092330	ENSG00000101849
Uniprot IDs		Q9BSI4	A0A024RBV9 O60907
PDB IDs		3BQO 3BU8 5XYF	2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?
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