TBL1X and HR

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TBL1X	HR
Description		transducin beta like 1 X-linked	HR lysine demethylase and nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcriptional Repressor Complex Mitotic Spindle	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Histone H3-K9 Demethylation Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases			Atrichia with papular lesions Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH)
GWAS		Prostate cancer ( 23535732)	Obesity-related traits ( 23251661)
Interacting Genes		28 interacting genes: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I	10 interacting genes: HDAC1 HDAC3 HDAC5 HMGB1 PRKCA RARA RARB TBL1X TRIM27 VDR
Entrez ID		6907	55806
HPRD ID		02183	03808
Ensembl ID		ENSG00000101849	ENSG00000168453
Uniprot IDs		A0A024RBV9 O60907	O43593
PDB IDs		2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?
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