GAS1 and DLK1

Number of citations of the paper that reports this interaction (PubMedID 11846389)
9

Data Source:
HPRD (two hybrid)

		GAS1	DLK1
Description		growth arrest specific 1	delta like non-canonical Notch ligand 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane	Extracellular Space Cytoplasm Integral Component Of Membrane
	Molecular Function	Protein Binding	Molecular_function Calcium Ion Binding
	Biological Process	Cell Cycle Arrest Regulation Of Smoothened Signaling Pathway Negative Regulation Of Protein Processing Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Mitotic Cell Cycle Developmental Growth Regulation Of ER To Golgi Vesicle-mediated Transport	Cell Differentiation Negative Regulation Of Notch Signaling Pathway
Pathways		Ligand-receptor interactions Activation of SMO	Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Borderline personality disorder ( 28632202) Heel bone mineral density ( 30598549) Insulin resistance/response ( 21901158) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Height ( 31562340) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 22139419 29403010) Type 1 diabetes ( 19966805)
Interacting Genes		5 interacting genes: BIRC2 CYB5R3 DLK1 ERRFI1 SHH	3 interacting genes: GAS1 GRN ZDHHC17
Entrez ID		2619	8788
HPRD ID		00747	01446
Ensembl ID		ENSG00000180447	ENSG00000185559
Uniprot IDs		P54826	A0A024R6L1 A8K019 P80370
PDB IDs
Enriched GO Terms of Interacting Partners?
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