PRPF31 and KCTD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF31	KCTD6
Description		pre-mRNA processing factor 31	potassium channel tetramerization domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex	Cytosol M Band
	Molecular Function	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Ribonucleoprotein Complex Binding SnRNP Binding	Protein Binding Ankyrin Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Growth Post-translational Protein Modification Negative Regulation Of Smoothened Signaling Pathway Protein Homooligomerization
Pathways		mRNA Splicing - Major Pathway	RUNX1 regulates estrogen receptor mediated transcription Neddylation Estrogen-dependent gene expression Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)	Hepcidin/transferrin saturation ratio ( 27846281) Systemic lupus erythematosus ( 28714469) vWF levels ( 30586737)
Interacting Genes		76 interacting genes: C1QTNF1 CALCOCO2 CBY2 CCDC136 CCDC33 CCDC57 CCNDBP1 CDCA7L CEP70 DVL2 EFEMP2 FANCA FANCC FASTK GOLGA2 HNRNPH2 HNRNPK JAKMIP2 KCTD6 KHDRBS2 KHDRBS3 KRT15 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 LDOC1 LURAP1 LZTS2 MDFI MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NDUFB9 NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PNMA1 PNMA2 PPIH PRICKLE1 PRPF3 PSTPIP1 RACK1 RBM25 RBM4 RBMX RBMY1A1 RBMY1F RINT1 SIAH1 SNRNP200 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM27 TRIM41 TSGA10 USP15 ZFP64 ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF587	17 interacting genes: ACTN1 ACTN3 ANK1 C8orf33 CDC23 CTNND1 EHHADH FAM124B GOLGA8EP GOLGA8F GRB7 GSDMD LNX1 PPIG PRPF31 SDCBP ZCCHC10
Entrez ID		26121	200845
HPRD ID		05917	13769
Ensembl ID		ENSG00000105618	ENSG00000168301
Uniprot IDs		Q8WWY3	Q8NC69
PDB IDs		2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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