GGA1 and F8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GGA1	F8
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 1	coagulation factor VIII
Image
GO Annotations	Cellular Component	Nucleoplasm Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein Binding ADP-ribosylation Factor Binding	Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Intracellular Protein Transport Protein Localization Protein Localization To Cell Surface Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Toxin Transport Protein Localization To Ciliary Membrane	Platelet Degranulation ER To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation COPII Vesicle Coating Oxidation-reduction Process
Pathways		TBC/RABGAPs Amyloid fiber formation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Cargo concentration in the ER
Drugs			Drotrecogin alfa Coagulation Factor IX (Recombinant) Anti-inhibitor coagulant complex Coagulation Factor IX Human
Diseases			Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Health literacy ( 31250787)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Factor VIII levels ( 30586737) Red blood cell traits ( 23446634) Thrombosis ( 26908601) Venous thromboembolism ( 31420334)
Interacting Genes		38 interacting genes: ADRA2B AFTPH AP1AR APP ARF1 ARF3 ARF5 BACE1 BACE2 C1orf216 CCDC91 CDKL3 CDKN2A CLINT1 CLTC CSNK2A1 DTNB EGFR F8 GGA2 GGA3 IGF2R LRP3 M6PR RABEP1 RABGEF1 RNF11 RPS27A SCARB1 SMAD3 SORL1 SORT1 STAB1 SYNRG TOLLIP TSG101 UBC VPS18	17 interacting genes: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 TSC22D2 UBQLN1 VWF
Entrez ID		26088	2157
HPRD ID		12078	02384
Ensembl ID		ENSG00000100083	ENSG00000185010
Uniprot IDs		Q9UJY5	P00451
PDB IDs		1J2J 1JWF 1JWG 1NA8 1NAF 1NWM 1O3X 1OM9 1OXZ 1PY1 1UJJ 1UJK 1X79 2DWX 2DWY 3G2S 3G2T 3G2U 3G2V 3G2W	1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV 4KI5 4PT6 4XZU 5K8D 6MF2
Enriched GO Terms of Interacting Partners?
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