ERC2 and PPFIA4

Number of citations of the paper that reports this interaction (PubMedID 12923177)
60

Data Source:
BioGRID (two hybrid, pull down, two hybrid)
HPRD (two hybrid, in vitro)

		ERC2	PPFIA4
Description		ELKS/RAB6-interacting/CAST family member 2	PTPRF interacting protein alpha 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Cytosol Cell Surface Synapse Presynaptic Active Zone
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding
	Biological Process	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure	Neurotransmitter Secretion Glutamate Secretion Synapse Organization
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Chronotype ( 26955885) Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Sense of smell ( 26632684) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 28416822 30061737 29892015) Early onset atrial fibrillation ( 28460022)
Interacting Genes		8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	6 interacting genes: AGTPBP1 CAST DNAJC5 ERC2 GIT1 NCOA2
Entrez ID		26059	8497
HPRD ID		10810	16012
Ensembl ID		ENSG00000187672	ENSG00000143847
Uniprot IDs		O15083	B3KN22 B4DIS5 O75335
PDB IDs
Enriched GO Terms of Interacting Partners?
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