ERC2 and PCLO

Number of citations of the paper that reports this interaction (PubMedID 14734538)
67

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		ERC2	PCLO
Description		ELKS/RAB6-interacting/CAST family member 2	piccolo presynaptic cytomatrix protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Cytoskeleton Postsynaptic Density Cell Junction Cell Projection Synapse Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure	Cytoskeleton Organization Synapse Assembly Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Synaptic Vesicle Clustering Presynapse To Nucleus Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Chronotype ( 26955885) Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Sense of smell ( 26632684) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) Major depressive disorder ( 21621269 28540843 20351715) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Rosacea symptom severity ( 29771307)
Interacting Genes		8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	3 interacting genes: ERC2 GIT1 GIT2
Entrez ID		26059	27445
HPRD ID		10810	16078
Ensembl ID		ENSG00000187672	ENSG00000186472
Uniprot IDs		O15083	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?