MOB4 and ARHGEF15

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		MOB4	ARHGEF15
Description		MOB family member 4, phocein	Rho guanine nucleotide exchange factor 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Golgi Cisterna Membrane Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm	Cytoplasm Dendrite
	Molecular Function	Protein Binding Kinase Binding Metal Ion Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process		Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28067908) Schizophrenia ( 29483656)	Bipolar disorder ( 28115744) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)
Interacting Genes		32 interacting genes: ARHGEF15 CCDC85B CRMP1 DNM1 EGFR EGLN2 ELK1 EPS15 FADD FBLN1 GDF9 KIDINS220 LATS1 LATS2 LRIF1 MCM2 MED10 MED31 MYL6 MYO9B NME2 PAICS PLEKHM1 PPIL3 PTPRS RAPGEF2 SCMH1 SETDB1 STK11 STK3 THAP4 UBE2V2	9 interacting genes: C11orf49 CEP55 DNAJC5 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1
Entrez ID		25843	22899
HPRD ID		10165	10535
Ensembl ID		ENSG00000115540	ENSG00000198844
Uniprot IDs		A0A024R3X9 Q9Y3A3	A0A0S2Z547 O94989
PDB IDs		5YF4
Enriched GO Terms of Interacting Partners?
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