NIPBL and DBN1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		NIPBL	DBN1
Description		NIPBL cohesin loading factor	drebrin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Nuclear Chromatin Nucleus Nucleoplasm Cytosol Integrator Complex SMC Loading Complex Intracellular Membrane-bounded Organelle Extracellular Exosome Scc2-Scc4 Cohesin Loading Complex	Cell Cytoplasm Cytoskeleton Actin Filament Plasma Membrane Gap Junction Postsynaptic Density Actin Cytoskeleton Lamellipodium Dendrite Growth Cone Site Of Polarized Growth Cortical Cytoskeleton Cortical Actin Cytoskeleton Actomyosin Postsynaptic Membrane Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding	Actin Binding Protein Binding Profilin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Mitotic Chromosome Condensation Brain Development Heart Development Sensory Perception Of Sound Stem Cell Population Maintenance Positive Regulation Of Histone Deacetylation Establishment Of Mitotic Sister Chromatid Cohesion Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis RDNA Condensation Establishment Of Protein Localization To Chromatin Cellular Response To X-ray Transcriptional Activation By Promoter-enhancer Looping Cohesin Loading Positive Regulation Of Mitotic Cohesin Loading Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Positive Regulation Of Neuron Migration	In Utero Embryonic Development Actin Filament Organization Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Maintenance Of Protein Location In Cell Positive Regulation Of Axon Extension Regulation Of Neuronal Synaptic Plasticity Neuron Projection Morphogenesis Regulation Of Dendrite Development Cytoplasmic Sequestering Of Protein Positive Regulation Of Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Receptor Localization To Synapse
Pathways		Cohesin Loading onto Chromatin
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Height ( 28552196 25282103 31562340) Obesity-related traits ( 23251661) Weight ( 28552196)	Activated partial thromboplastin time ( 22703881) Extremely high intelligence ( 29520040) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: CBX5 CDK6 DBN1 HINFP PRSS23 SP100	27 interacting genes: ACD BAK1 BTRC CDK2AP2 DNMBP DUSP23 ESR1 FHL1 HOMER2 MAP1LC3B MAPK6 MEST NIPBL NUDT21 NUDT3 PFN1 POT1 PTEN RABGAP1L SNUPN SUPT5H TAB1 TERF1 TINF2 TPT1 UBE2D3 ZNF598
Entrez ID		25836	1627
HPRD ID		10560	00545
Ensembl ID		ENSG00000164190	ENSG00000113758
Uniprot IDs		A0A590UJS4 Q6KC79	Q16643
PDB IDs			5Y1Z 5ZZ9
Enriched GO Terms of Interacting Partners?
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