SPDEF and PCGF2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		SPDEF	PCGF2
Description		SAM pointed domain containing ETS transcription factor	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway
Pathways			SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 28552196) Inflammatory bowel disease ( 27569725) Weight ( 28552196)
Interacting Genes		5 interacting genes: AR NKX3-1 PCGF2 SRPK2 STK11	21 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC2 RBCK1 RNF2 SPDEF UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		25803	7703
HPRD ID		12176	10621
Ensembl ID		ENSG00000124664	ENSG00000277258
Uniprot IDs		O95238	A0A024R1V6 P35227
PDB IDs		1YO5 2DKX
Enriched GO Terms of Interacting Partners?
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