KCNE4 and KCNQ1

Number of citations of the paper that reports this interaction (PubMedID 12670483)
8

Data Source:
HPRD (in vivo)

		KCNE4	KCNQ1
Description		potassium voltage-gated channel subfamily E regulatory subunit 4	potassium voltage-gated channel subfamily Q member 1
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Potassium Channel Complex Apical Plasma Membrane	Cytoplasm Lysosome Early Endosome Late Endosome Endoplasmic Reticulum Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Ion Channel Complex Membrane Raft
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Calmodulin Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Phosphatase 1 Binding Outward Rectifier Potassium Channel Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Regulation Of Gene Expression By Genetic Imprinting Sensory Perception Of Sound Regulation Of Heart Contraction Positive Regulation Of Heart Rate Gene Silencing Cellular Response To Drug Inner Ear Development Intestinal Absorption Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of Gastric Acid Secretion Cardiac Conduction Renal Absorption Cellular Response To CAMP Potassium Ion Transmembrane Transport Cellular Response To Epinephrine Stimulus Cardiovascular System Development Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Indapamide Bepridil Azimilide ICA-105665
Diseases			Type II diabetes mellitus Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Mean platelet volume ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)	Birth weight ( 31043758) Blood pressure measurement (high sodium intervention) ( 24165912) Blood sugar levels ( 29403010) Body mass index ( 24861553 28892062) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Electrocardiographic traits ( 20062063 25055868) Estimated glomerular filtration rate ( 31152163 31451708 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 28898252) Gout ( 25967671) Height ( 28552196 20881960 25282103 25429064 31562340) Hemoglobin A1c levels ( 29403010) Hyperuricemia ( 29124443) Medication use (drugs used in diabetes) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Mosquito bite size ( 28199695) Offspring birth weight ( 31043758) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet aggregation ( 20526338) Protein quantitative trait loci ( 18464913) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409) Serum uric acid levels ( 29124443) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Type 2 diabetes ( 21573907 22885922 24509480 24101674 30054458 18711366 18711367 26961502 25102180 30297969 28254843 26818947 21799836 28406950 23945395 31118516 22961080 20581827 19401414 24390345 30718926 28869590 20174558) Urate levels ( 31578528) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		7 interacting genes: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TSNAX	8 interacting genes: AKAP9 KCNE1 KCNE2 KCNE4 NUP98 PPP1CA PRKACA TRAF6
Entrez ID		23704	3784
HPRD ID		09689	06341
Ensembl ID		ENSG00000152049	ENSG00000053918
Uniprot IDs		A5H1P5 Q8WWG9	P51787 Q96AI9
PDB IDs			3BJ4 3HFC 3HFE 4UMO 4V0C
Enriched GO Terms of Interacting Partners?
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