KCNE4 and FLNA

Number of citations of the paper that reports this interaction (PubMedID 20498229)
13

Data Source:
BioGRID (two hybrid)

		KCNE4	FLNA
Description		potassium voltage-gated channel subfamily E regulatory subunit 4	filamin A
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Potassium Channel Complex Apical Plasma Membrane	Extracellular Region Nucleus Nucleolus Cytoplasm Cytosol Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Z Disc Growth Cone Cortical Cytoskeleton Myb Complex Dendritic Shaft Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome Apical Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	G Protein-coupled Receptor Binding RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Rho GTPase Binding Ral GTPase Binding Kinase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Ion Channel Binding Cadherin Binding SMAD Binding Rac GTPase Binding Actin Filament Binding GTPase Binding
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase I Formation Of Radial Glial Scaffolds Cerebral Cortex Development Platelet Activation Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA-binding Transcription Factor Activity Wound Healing, Spreading Of Cells Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Defense Response To Virus Actin Crosslink Formation Cilium Assembly Platelet Aggregation Semaphorin-plexin Signaling Pathway Protein Localization To Plasma Membrane Tubulin Deacetylation Mitotic Spindle Assembly Establishment Of Sertoli Cell Barrier Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Potassium Ion Transmembrane Transport Protein Localization To Bicellular Tight Junction Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Integrin-mediated Signaling Pathway Positive Regulation Of Neuron Migration
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response
Drugs			Artenimol
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia Periventricular nodular heterotopia (PVNH) FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Body mass index ( 20966902) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Logical memory (delayed recall) in normal cognition ( 29274321) Mean platelet volume ( 27863252) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist circumference ( 20966902) Weight ( 28552196)
Interacting Genes		7 interacting genes: FLNA KCNA1 KCNQ1 OBSL1 PRKCA TCF7L2 TSNAX	87 interacting genes: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA1 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MCPH1 MTDH MTNR1A MTNR1B MYOT NLGN3 NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RFLNA RHOA SELE SH2B3 SHBG SIGLEC10 SIRPA SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TP73 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG
Entrez ID		23704	2316
HPRD ID		09689	02060
Ensembl ID		ENSG00000152049	ENSG00000196924
Uniprot IDs		A5H1P5 Q8WWG9	P21333 Q60FE5 Q6NXF2
PDB IDs			2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2MTP 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH 4M9P 4P3W 5XR1 6D8C 6EW1
Enriched GO Terms of Interacting Partners?
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