FPR1 and SAA1

Number of citations of the paper that reports this interaction (PubMedID 10753626)
24

Data Source:
HPRD (in vitro)

		FPR1	SAA1
Description		formyl peptide receptor 1	serum amyloid A1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Cell Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	G Protein-coupled Receptor Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding RAGE Receptor Binding	G Protein-coupled Receptor Binding Heparin Binding Chemoattractant Activity
	Biological Process	Activation Of MAPK Activity Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Degranulation	Activation Of MAPK Activity Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response Positive Chemotaxis Cell Chemotaxis
Pathways		G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-10 signaling Neutrophil degranulation	Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation
Drugs		Nedocromil	Human Serum Albumin
Diseases
GWAS		Alopecia areata ( 25608926) Neutrophil percentage of granulocytes ( 27863252) Tourette syndrome ( 30818990)	Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)
Interacting Genes		5 interacting genes: ACTG1 ANXA1 GNAI2 GRK2 SAA1	10 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R GNG5 LAMA1 SELENOS VKORC1
Entrez ID		2357	6288
HPRD ID		00646	00097
Ensembl ID		ENSG00000171051	ENSG00000173432
Uniprot IDs		P21462	P0DJI8
PDB IDs			4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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