POFUT1 and ZIC3

		POFUT1	ZIC3
Description		protein O-fucosyltransferase 1	Zic family member 3
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation	Heart Looping Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Central Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation Lung Development Somatic Stem Cell Population Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		13 interacting genes: AKT2 DEFB115 DEFB116 DLL1 DUSP15 ERGIC3 ID1 JAG1 NAP1L2 NOTCH1 PTPRA USH2A ZIC3	6 interacting genes: CTNNB1 GLI3 POFUT1 SRF TP53 TWIST1
Entrez ID		23509	7547
HPRD ID		06319	02225
Ensembl ID		ENSG00000101346	ENSG00000156925
Uniprot IDs		Q9H488	O60481
PDB IDs		5UX6 5UXH	2EJ4 2RPC
Enriched GO Terms of Interacting Partners?
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