ZFPM2 and CTBP1

Number of citations of the paper that reports this interaction (PubMedID 10438528)
29

Data Source:
HPRD (two hybrid)

		ZFPM2	CTBP1
Description		zinc finger protein, FOG family member 2	C-terminal binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Transcriptional Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Gonadal Mesoderm Development Heart Development Blood Coagulation Cell Differentiation Lung Development Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation
Pathways		Factors involved in megakaryocyte development and platelet production	Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes TCF7L2 mutants don't bind CTBP
Drugs			Formic Acid
Diseases		Tetralogy of Fallot
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Glaucoma (primary open-angle) ( 22570617) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 26805783 22139419 29403010 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) PR interval ( 30046033) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 26910538 21757650) Venous thromboembolism ( 25772935 28373160 31420334 31676865) White blood cell count (basophil) ( 27863252)	Type 2 diabetes ( 31118516)
Interacting Genes		11 interacting genes: CTBP1 CTBP2 E2F6 EP300 GATA1 GATA3 GATA4 IL32 ITSN1 STAT3 UBQLN4	92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		23414	1487
HPRD ID		04737	04015
Ensembl ID		ENSG00000169946	ENSG00000159692
Uniprot IDs		Q8WW38 Q9NPQ0	Q13363 X5D8Y5
PDB IDs			1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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