CTBP1 and CEP68

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CTBP1	CEP68
Description		C-terminal binding protein 1	centrosomal protein 68
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Nucleoplasm Centrosome Cytosol Cell Junction Centriolar Satellite
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Identical Protein Binding NAD Binding Repressing Transcription Factor Binding	Protein Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Protein Phosphorylation Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation	Centrosome Cycle Centriole-centriole Cohesion Protein Localization To Organelle
Pathways		Deactivation of the beta-catenin transactivating complex SUMOylation of transcription cofactors Repression of WNT target genes TCF7L2 mutants don't bind CTBP
Drugs		Formic Acid
Diseases
GWAS		Type 2 diabetes ( 31118516)	Atrial fibrillation ( 28416818 28416822 30061737 29892015) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878 30578418) Triglycerides ( 30275531 25961943) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		92 interacting genes: ACTL6B AKAP9 APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CDKN2D CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FANCC FANCF FANCG FANCL FOXP1 FOXP2 FUNDC1 GTF2B H3-4 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCORL LNX1 MAML2 MAPK9 MARCHF10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 NTAQ1 ORC4 PIAS2 PLCB1 PNN PRKAA1 PRKCI RAI2 RB1 RBBP5 RBBP8 RBM14 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TEAD4 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219	7 interacting genes: AAK1 CTBP1 LGALSL MCM7 SERTAD2 SNRNP27 USHBP1
Entrez ID		1487	23177
HPRD ID		04015	13808
Ensembl ID		ENSG00000159692	ENSG00000011523
Uniprot IDs		Q13363 X5D8Y5	Q76N32
PDB IDs		1MX3 4LCE 4U6Q 4U6S 6CDF 6CDR
Enriched GO Terms of Interacting Partners?
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