SIRT3 and ACADVL

Number of citations of the paper that reports this interaction (PubMedID 25811481)
22

Data Source:
BioGRID (enzymatic study)

		SIRT3	ACADVL
Description		sirtuin 3	acyl-CoA dehydrogenase very long chain
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Protein-containing Complex	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Mitochondrial Membrane Mitochondrial Nucleoid
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Enzyme Binding NAD-dependent Protein Deacetylase Activity Sequence-specific DNA Binding NAD+ Binding	Fatty-acyl-CoA Binding Long-chain-acyl-CoA Dehydrogenase Activity Very-long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Protein ADP-ribosylation Protein Deacetylation Mitochondrion Organization Aging Aerobic Respiration Histone Deacetylation Positive Regulation Of Insulin Secretion Peptidyl-lysine Deacetylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Superoxide Dismutase Activity Positive Regulation Of Catalase Activity Positive Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Temperature Homeostasis Fatty Acid Beta-oxidation Response To Cold Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase IRE1-mediated Unfolded Protein Response Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process
Pathways		Transcriptional activation of mitochondrial biogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation	XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Drugs		Adenosine-5-Diphosphoribose
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Menarche (age at onset) ( 25231870) Platelet count ( 24026423) Uterine fibroids ( 21460842 30194396)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: ACADVL ALDH2 DNM1L H3C1 MDM2 PDP1 PEX5 XRCC6	4 interacting genes: GPHN RPSA SIRT3 SOCS3
Entrez ID		23410	37
HPRD ID		06836	01940
Ensembl ID		ENSG00000142082	ENSG00000072778
Uniprot IDs		Q9NTG7	B3KPA6 P49748
PDB IDs		3GLR 3GLS 3GLT 3GLU 4BN4 4BN5 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH 4C78 4C7B 4FVT 4FZ3 4HD8 4JSR 4JT8 4JT9 4O8Z 5BWN 5BWO 5D7N 5H4D 5Y4H 5YTK 5Z93 5Z94 5ZGC 6ISO	2UXW 3B96
Enriched GO Terms of Interacting Partners?
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