ACADVL and SOCS3

Number of citations of the paper that reports this interaction (PubMedID 22093833)
2

Data Source:
BioGRID (pull down)

		ACADVL	SOCS3
Description		acyl-CoA dehydrogenase very long chain	suppressor of cytokine signaling 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Mitochondrial Membrane Mitochondrial Nucleoid	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Fatty-acyl-CoA Binding Long-chain-acyl-CoA Dehydrogenase Activity Very-long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Temperature Homeostasis Fatty Acid Beta-oxidation Response To Cold Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase IRE1-mediated Unfolded Protein Response Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		Metabolite levels ( 23823483)	Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)
Interacting Genes		4 interacting genes: GPHN RPSA SIRT3 SOCS3	54 interacting genes: ABL1 ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXNDC11 YES1 YWHAQ
Entrez ID		37	9021
HPRD ID		01940	05006
Ensembl ID		ENSG00000072778	ENSG00000184557
Uniprot IDs		B3KPA6 P49748	O14543 Q6FI39
PDB IDs		2UXW 3B96
Enriched GO Terms of Interacting Partners?
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