SIN3B and IKZF4

Number of citations of the paper that reports this interaction (PubMedID 12015313)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SIN3B	IKZF4
Description		SIN3 transcription regulator family member B	IKAROS family zinc finger 4
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin X Chromosome Y Chromosome XY Body Nucleus Nucleoplasm Cytoplasm Sin3 Complex Autosome	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylation Regulation Of Lipid Metabolic Process	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization
Pathways		NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 21804548 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)
Interacting Genes		22 interacting genes: AURKA COPS2 GDF15 H3-4 HDAC1 HDAC9 IKZF1 IKZF4 MAD1L1 MXD1 MXI1 NR1D2 POR REST RNF220 SETDB1 SMARCA2 SMARCA4 SMARCB1 SMARCE1 TP53 ZBTB16	12 interacting genes: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B
Entrez ID		23309	64375
HPRD ID		09691	05874
Ensembl ID		ENSG00000127511	ENSG00000123411
Uniprot IDs		B7Z392 M0QYC5 O75182	Q9H2S9
PDB IDs			2MA7
Enriched GO Terms of Interacting Partners?
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