IKZF4 and NRG1

Number of citations of the paper that reports this interaction (PubMedID 15494726)
68

Data Source:
HPRD (in vivo, in vitro)

		IKZF4	NRG1
Description		IKAROS family zinc finger 4	neuregulin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Integral Component Of Plasma Membrane Membrane Axon Neuromuscular Junction Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity ErbB-2 Class Receptor Binding Integrin Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity
	Biological Process	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization	MAPK Cascade Activation Of MAPK Activity Cell Morphogenesis Cardiac Conduction System Development Ventricular Trabecula Myocardium Morphogenesis Cell Communication Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Synapse Assembly Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Neural Crest Cell Development Glial Cell Fate Commitment Chemorepulsion Involved In Interneuron Migration From The Subpallium To The Cortex Myelination In Peripheral Nervous System Cell Differentiation Mammary Gland Development Positive Regulation Of Protein Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway Wound Healing Negative Regulation Of Protein Catabolic Process Neurotransmitter Receptor Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Animal Organ Development Neuron Fate Commitment Oligodendrocyte Differentiation Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Postsynapse To Nucleus Signaling Pathway Regulation Of Cell Motility Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Neuron Migration
Pathways			Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 21804548 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)	Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cleft lip with or without cleft palate ( 28054174) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 25310821 27702942) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Orofacial clefts ( 28054174) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		12 interacting genes: CHD4 FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 NFKBIA NRG1 SIN3A SIN3B	8 interacting genes: ADAM19 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 LIMK1
Entrez ID		64375	3084
HPRD ID		05874	00802
Ensembl ID		ENSG00000123411	ENSG00000157168
Uniprot IDs		Q9H2S9	A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 F6RJN6 Q02297 Q6PK61 Q7RTW3 Q7RTW5
PDB IDs		2MA7	1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?
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