MLC1 and MYLK

Number of citations of the paper that reports this interaction (PubMedID 10092231)
178

Data Source:
BioGRID (enzymatic study)

		MLC1	MYLK
Description		modulator of VRAC current 1	myosin light chain kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Caveola Cell-cell Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Astrocyte End-foot	Stress Fiber Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Lamellipodium Cleavage Furrow
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding	Actin Binding Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Ion Transport Protein Transport Vesicle-mediated Transport Positive Regulation Of Intracellular Transport Regulation Of Response To Osmotic Stress Cellular Response To Cholesterol Caveolin-mediated Endocytosis	Protein Phosphorylation Muscle Contraction Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Cell Migration Bleb Assembly Positive Regulation Of Calcium Ion Transport Aorta Smooth Muscle Tissue Morphogenesis Cellular Hypotonic Response Cardiovascular System Development Positive Regulation Of Wound Healing
Pathways			Smooth Muscle Contraction RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases		Megalencephalic leukoencephalopathy with subcortical cysts (MLC)	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Acne (severe) ( 24927181) Body mass index (adult) ( 28430825)	General cognitive ability ( 29844566)
Interacting Genes		7 interacting genes: DAPK2 KDM1A MYLK NAT14 PRMT6 ROCK1 TPT1	14 interacting genes: ACTA1 ACTC1 CALM1 CAMK2G CTTN GOPC HSPB1 MAPK3 MLC1 PAK1 PAK2 PRKCA PRKG2 SRC
Entrez ID		23209	4638
HPRD ID		05800	02952
Ensembl ID		ENSG00000100427	ENSG00000065534
Uniprot IDs		A0A024R4V4 Q15049	Q05B97 Q05B98 Q15746
PDB IDs			2CQV 2K0F 2YR3 5JQA 5JTH 6C6M
Enriched GO Terms of Interacting Partners?
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