FLI1 and ELK1

Number of citations of the paper that reports this interaction (PubMedID 9010223)
30

Data Source:
BioGRID (pull down)

		FLI1	ELK1
Description		Fli-1 proto-oncogene, ETS transcription factor	ETS transcription factor ELK1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Nuclear Body	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Hemostasis Blood Circulation Animal Organ Morphogenesis Cell Differentiation Megakaryocyte Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Testosterone Stimulus Cellular Response To Gamma Radiation Response To Fibroblast Growth Factor Positive Regulation Of Neuron Death
Pathways		Transcriptional regulation of granulopoiesis	ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases		Ewing's sarcoma
GWAS		Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Corneal astigmatism ( 30306274) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Heel bone mineral density ( 30598549) Height ( 20881960 31562340) Left ventricular obstructive tract defect (inherited effect) ( 28468790) Myopia (pathological) ( 23049088) Non-albumin protein levels ( 29403010) Platelet count ( 27863252) Plateletcrit ( 27863252) Rheumatoid arthritis ( 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 26502338) Vitiligo ( 27723757)
Interacting Genes		18 interacting genes: BRCA1 CTBP2 ELK1 ERG ETV6 EWSR1 GATA1 KLF1 PIAS1 PIAS2 PRKCD SIAH1 SMAD3 SMAD9 SOX30 SRF TDP2 UBE2I	40 interacting genes: AKAP8 APP BRCA1 CDK6 CEBPB CREBBP CRK EMX1 EP300 EWSR1 FBXO25 FLI1 FOS GRB10 GRB2 HDAC1 HOXB13 ID1 ID2 ID3 KLF4 MAD2L2 MAP2K1 MAP2K3 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MOB4 PIAS2 PLCG2 SNCA SRF STARD3NL STK16 TAOK2 UBE2I
Entrez ID		2313	2002
HPRD ID		01901	02407
Ensembl ID		ENSG00000151702	ENSG00000126767
Uniprot IDs		A0A024R3K4 A0A024R3M5 A0A024R3N6 Q01543	A0A024R1A7 P19419 Q86SR6
PDB IDs		1FLI 1X66 2YTU 5E8G 5E8I 5JVT	1DUX 5VVT
Enriched GO Terms of Interacting Partners?
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