NFASC and SCN1B

Number of citations of the paper that reports this interaction (PubMedID 11470829)
61

Data Source:
HPRD (in vivo)

		NFASC	SCN1B
Description		neurofascin	sodium voltage-gated channel beta subunit 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Schwann Cell Microvillus Ficolin-1-rich Granule Membrane	Voltage-gated Sodium Channel Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc T-tubule Node Of Ranvier Perikaryon
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Neutrophil Degranulation Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane	Cell Adhesion Axon Guidance Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Neuronal Action Potential Propagation Corticospinal Neuron Axon Guidance Sodium Ion Transmembrane Transport Locomotion Response To Pyrethroid Membrane Depolarization Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Voltage-gated Sodium Channel Activity Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Phenytoin Valproic Acid Zonisamide Brivaracetam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Brugada syndrome (BRS)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) Mean platelet volume ( 27863252) Regular attendance at a religious group ( 29970889)	Metabolite levels ( 23823483) Serum albumin level ( 23022100)
Interacting Genes		10 interacting genes: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	3 interacting genes: ANK3 NFASC SCN2B
Entrez ID		23114	6324
HPRD ID		12372	02581
Ensembl ID		ENSG00000163531	ENSG00000105711
Uniprot IDs		B4DRH7 O94856	A0A1W2PR05 Q07699
PDB IDs		3P3Y 3P40	6AGF 6J8G 6J8H 6J8I 6J8J
Enriched GO Terms of Interacting Partners?
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