NFASC and SCN3B

Number of citations of the paper that reports this interaction (PubMedID 11470829)
61

Data Source:
HPRD (in vivo)

		NFASC	SCN3B
Description		neurofascin	sodium voltage-gated channel beta subunit 3
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Schwann Cell Microvillus Ficolin-1-rich Granule Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Voltage-gated Ion Channel Activity Protein Binding Sodium Channel Regulator Activity Sodium Channel Inhibitor Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Neutrophil Degranulation Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Neurofascin interactions Neurofascin interactions Neutrophil degranulation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Valproic Acid Zonisamide Brivaracetam
Diseases			Brugada syndrome (BRS)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576 29875488 28240269) Clozapine-induced agranulocytosis ( 25187353) Dental caries ( 23064961) Diisocyanate-induced asthma ( 25918132) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) General risk tolerance (MTAG) ( 30643258) Mean platelet volume ( 27863252) Regular attendance at a religious group ( 29970889)	Chronic lymphocytic leukemia ( 28165464 24292274 23770605) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		10 interacting genes: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	2 interacting genes: NFASC NLRX1
Entrez ID		23114	55800
HPRD ID		12372	10497
Ensembl ID		ENSG00000163531	ENSG00000166257
Uniprot IDs		B4DRH7 O94856	A0A024R3H7 Q9NY72
PDB IDs		3P3Y 3P40	4L1D
Enriched GO Terms of Interacting Partners?
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