TNIK and PPM1E

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		TNIK	PPM1E
Description		TRAF2 and NCK interacting kinase	protein phosphatase, Mg2+/Mn2+ dependent 1E
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol Protein-containing Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Signal Transduction By Protein Phosphorylation Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Negative Regulation Of Protein Kinase Activity Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly
Pathways		Oxidative Stress Induced Senescence	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 27863252) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Type 2 diabetes ( 30054458)	Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)
Interacting Genes		37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1	5 interacting genes: ARHGEF7 DISC1 GAPDH PRKAA1 TNIK
Entrez ID		23043	22843
HPRD ID		18206	17888
Ensembl ID		ENSG00000154310	ENSG00000175175
Uniprot IDs		Q9UKE5	Q8WY54
PDB IDs		2X7F 5AX9 5CWZ 5D7A 6RA7
Enriched GO Terms of Interacting Partners?
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