PPM1E and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 11864573)
36

Data Source:
BioGRID (pull down)

		PPM1E	ARHGEF7
Description		protein phosphatase, Mg2+/Mn2+ dependent 1E	Rho guanine nucleotide exchange factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Cytosol Protein-containing Complex	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly	Golgi Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Negative regulation of NMDA receptor-mediated neuronal transmission	EGFR downregulation NRAGE signals death through JNK Rho GTPase cycle Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)	Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824)
Interacting Genes		5 interacting genes: ARHGEF7 DISC1 GAPDH PRKAA1 TNIK	33 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		22843	8874
HPRD ID		17888	05688
Ensembl ID		ENSG00000175175	ENSG00000102606
Uniprot IDs		Q8WY54	A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1
PDB IDs			1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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