MAST3 and GDF15

		MAST3	GDF15
Description		microtubule associated serine/threonine kinase 3	growth differentiation factor 15
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GO Annotations	Cellular Component		Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Cytoskeleton Organization Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
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Drugs
Diseases
GWAS		Body fat mass ( 28552196) Glycine levels ( 30837465) Mental health study participation (completed survey) ( 31263887) Number of sexual partners ( 30643258) Urate levels ( 31578528)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		4 interacting genes: CNTNAP4 GDF15 MYCBP2 PTEN	16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1
Entrez ID		23031	9518
HPRD ID		19403	05608
Ensembl ID		ENSG00000099308	ENSG00000130513
Uniprot IDs		O60307	Q99988
PDB IDs		1V9V 3KHF	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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