ACIN1 and AKR1C3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		ACIN1	AKR1C3
Description		apoptotic chromatin condensation inducer 1	aldo-keto reductase family 1 member C3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Nuclear Speck ASAP Complex	Intracellular Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding ATPase Activity Enzyme Binding	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Alcohol Dehydrogenase (NADP+) Activity Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Bile Acid Binding Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity Delta4-3-oxosteroid 5beta-reductase Activity NADP-retinol Dehydrogenase Activity
	Biological Process	MRNA Processing RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation	Retinoid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process C21-steroid Hormone Metabolic Process Positive Regulation Of Cell Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Macromolecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Apoptotic cleavage of cellular proteins	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of Prostaglandins (PG) and Thromboxanes (TX) RA biosynthesis pathway Retinoid metabolism and transport
Drugs			NADH Indomethacin Bimatoprost Androstenedione Rutin Prostaglandin D2 Flufenamic Acid 2'-Monophosphoadenosine 5'-Diphosphoribose 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN
Diseases
GWAS			Epithelial ovarian cancer ( 31469419)
Interacting Genes		10 interacting genes: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 PAFAH1B2 PCBD1 SRPK2 YWHAG	6 interacting genes: ACIN1 LRIF1 MAGEA11 SIAH2 UBE2W ZHX1
Entrez ID		22985	8644
HPRD ID		05191	04911
Ensembl ID		ENSG00000100813	ENSG00000196139
Uniprot IDs		B4DQZ7 Q9UKV3	A0A0A0MSS8 B4DKT3 P42330
PDB IDs		6G6S	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WDT 4WDU 4WDW 4WDX 4WRH 4XVD 4XVE 4YVV 4YVX 4ZFC 5HNT 5HNU 5JM5 6A7B 6F2U 6F78 6GXK
Enriched GO Terms of Interacting Partners?
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