RALY and SPG7

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RALY	SPG7
Description		RALY heterogeneous nuclear ribonucleoprotein	SPG7 matrix AAA peptidase subunit, paraplegin
Image
GO Annotations	Cellular Component	Nucleus Catalytic Step 2 Spliceosome	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Axon Cytoplasm
	Molecular Function	Transcription Coregulator Activity RNA Binding Protein Binding	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Cholesterol Homeostasis Regulation Of Nucleic Acid-templated Transcription	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Basal cell carcinoma ( 31174203 27539887) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 22976474) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Estimated glomerular filtration rate ( 31451708) Facial pigmentation ( 25705849) Hair color ( 29662168) Idiopathic dilated cardiomyopathy ( 29495422) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Melanoma ( 28212542) Non-melanoma skin cancer ( 29739929) Red vs. brown/black hair color ( 30531825) Skin colour saturation ( 25963972) Skin sensitivity to sun ( 25963972) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell carcinoma ( 26829030) Type 2 diabetes ( 30297969) Vitiligo ( 27723757) Weight ( 28552196)	Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		11 interacting genes: CELF1 HNRNPC HNRNPD HNRNPH1 HNRNPK KHDRBS1 PCBP1 PIK3CD QKI SPG7 WDR62	25 interacting genes: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		22913	6687
HPRD ID		11480	04149
Ensembl ID		ENSG00000125970	ENSG00000197912
Uniprot IDs		Q53GL6 Q9UKM9	A0A2R8Y632 Q9UQ90
PDB IDs		1WF1	2QZ4
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?