SPG7 and SPATS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SPG7	SPATS1
Description		SPG7 matrix AAA peptidase subunit, paraplegin	spermatogenesis associated serine rich 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Axon Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways		Processing of SMDT1
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)	Itch intensity from mosquito bite adjusted by bite size ( 28199695)
Interacting Genes		25 interacting genes: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28	3 interacting genes: CFLAR GPHN SPG7
Entrez ID		6687	221409
HPRD ID		04149	10248
Ensembl ID		ENSG00000197912	ENSG00000249481
Uniprot IDs		A0A2R8Y632 Q9UQ90	Q496A3
PDB IDs		2QZ4
Enriched GO Terms of Interacting Partners?
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