SEC31A and ARIH1

Number of citations of the paper that reports this interaction (PubMedID 27565346)
35

Data Source:
BioGRID (enzymatic study)

		SEC31A	ARIH1
Description		SEC31 homolog A, COPII coat complex component	ariadne RBR E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Ubiquitin Ligase Complex Cytoplasm Cytosol Cajal Body Nuclear Body SCF Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Lewy Body
	Molecular Function	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II IRE1-mediated Unfolded Protein Response COPII Vesicle Coating Response To Calcium Ion Cargo Loading Into COPII-coated Vesicle COPII-coated Vesicle Budding	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ISG15 antiviral mechanism
Drugs
Diseases
GWAS		Adult asthma ( 27611488) Neutrophil percentage of white cells ( 27863252)
Interacting Genes		12 interacting genes: APC ARIH1 KLHL12 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC22D2 USP8	16 interacting genes: CCNE1 CDKN1B CRY1 DCUN1D1 EIF4E2 HSPB1 PLD1 SEC31A UBC UBE2D1 UBE2D3 UBE2E2 UBE2L3 UBE2L6 UBE2N VAV2
Entrez ID		22872	25820
HPRD ID		15314	05730
Ensembl ID		ENSG00000138674	ENSG00000166233
Uniprot IDs		A0A024RDH6 A1LU61 O94979	Q9Y4X5
PDB IDs		3WXA	1WD2 2M9Y 4KBL 4KC9 5TTE 5UDH
Enriched GO Terms of Interacting Partners?
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