VEGFD and FLT4

Number of citations of the paper that reports this interaction (PubMedID 9435229)
218

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		VEGFD	FLT4
Description		vascular endothelial growth factor D	fms related receptor tyrosine kinase 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Extracellular Region Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 3 Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding VEGF-C-activated Receptor Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Platelet Degranulation Cell Proliferation Positive Regulation Of Cell Proliferation Response To Bacterium Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Dopaminergic Neuron Differentiation	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Sorafenib Sunitinib Vatalanib TG-100801 ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib
Diseases		Gastric cancer	Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS			Blood protein levels ( 30072576 29875488) Serum folate levels ( 29953918)
Interacting Genes		4 interacting genes: FLT4 ITGA9 KDR VAMP3	16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD
Entrez ID		2277	2324
HPRD ID		02102	00636
Ensembl ID		ENSG00000165197	ENSG00000037280
Uniprot IDs		O43915	P35916
PDB IDs		2XV7	4BSJ 4BSK
Enriched GO Terms of Interacting Partners?
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