FLT4 and DUSP19

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		FLT4	DUSP19
Description		fms related receptor tyrosine kinase 4	dual specificity phosphatase 19
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding VEGF-C-activated Receptor Activity Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity	Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Phosphatase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymph Vessel Development Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Blood Vessel Morphogenesis Regulation Of Blood Vessel Remodeling Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Kinase C Signaling	Negative Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Peptidyl-tyrosine Dephosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JUN Kinase Activity Positive Regulation Of Protein Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
Pathways		VEGF binds to VEGFR leading to receptor dimerization NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 ABT-869 IMC-1C11 Pazopanib Axitinib Regorafenib Lenvatinib Nintedanib
Diseases		Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS		Blood protein levels ( 30072576 29875488) Serum folate levels ( 29953918)
Interacting Genes		16 interacting genes: ATF7IP DUSP19 ERBB2 GRB2 IKBKG ITGA5 ITGB1 KDR LRRK1 NEDD4 PTK2 PTPN11 SHC1 SHC3 VEGFC VEGFD	18 interacting genes: ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2
Entrez ID		2324	142679
HPRD ID		00636	13254
Ensembl ID		ENSG00000037280	ENSG00000162999
Uniprot IDs		P35916	Q8WTR2
PDB IDs		4BSJ 4BSK	3S4E 4D3P 4D3Q 4D3R
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?