FCN1 and ELN

Number of citations of the paper that reports this interaction (PubMedID 8947836)
6

Data Source:
HPRD (in vitro)

		FCN1	ELN
Description		ficolin 1	elastin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extrinsic Component Of External Side Of Plasma Membrane Secretory Granule Lumen Collagen-containing Extracellular Matrix Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix Elastic Fiber
	Molecular Function	G Protein-coupled Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Complement Activation, Lectin Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Complement Activation G Protein-coupled Receptor Signaling Pathway Protein Localization To Cell Surface Neutrophil Degranulation Recognition Of Apoptotic Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Interleukin-8 Secretion	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation	Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs			Rofecoxib
Diseases			Congenital supravalvar aortic stenosis Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Blood protein levels ( 30072576 29875488 28240269) Trans-epidermal water loss ( 28011148)	Diverticular disease ( 30177863) Height ( 31562340)
Interacting Genes		2 interacting genes: ELN TGFB1	22 interacting genes: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PRTN3 SPINK1
Entrez ID		2219	2006
HPRD ID		03153	00556
Ensembl ID		ENSG00000085265	ENSG00000049540
Uniprot IDs		O00602	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?
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