MARCHF8 and CD86

Number of citations of the paper that reports this interaction (PubMedID 12582153)
58

Data Source:
HPRD (in vitro, in vivo)

		MARCHF8	CD86
Description		membrane associated ring-CH-type finger 8	CD86 molecule
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response	Adaptive Immune Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Lymphotoxin A Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways			PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept
Diseases
GWAS			Diffuse large B cell lymphoma ( 25261932) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 31604244 22190364 24076602 21833088 27386562) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		5 interacting genes: CD86 IL1RAP UBE2D1 UBE2D3 UBE2H	6 interacting genes: CD28 CD80 CTLA4 ECE2 MARCHF8 PARP1
Entrez ID		220972	942
HPRD ID		17466	03011
Ensembl ID		ENSG00000165406	ENSG00000114013
Uniprot IDs		A0A024R7U2 Q5T0T0	A0A0X9R4E0 A8K632 P42081
PDB IDs		2D8S	1I85 1NCN 5YXK
Enriched GO Terms of Interacting Partners?
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