FAM124A and FOXP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FAM124A	FOXP2
Description		family with sequence similarity 124 member A	forkhead box P2
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromatin
	Molecular Function	Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Skeletal Muscle Tissue Development Post-embryonic Development Cerebellum Development Caudate Nucleus Development Putamen Development Cerebral Cortex Development Response To Testosterone Vocal Learning Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Lung Alveolus Development Smooth Muscle Tissue Development Righting Reflex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Innate Vocalization Behavior
Pathways
Drugs
Diseases			Speech-language disorder 1 (SPCH1)
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Lipoprotein (a) levels ( 30108283) Metabolite levels ( 23823483) Placental abruption ( 29884306) Rheumatoid arthritis (ACPA-negative) ( 24532677)	Adventurousness ( 30643258) Age at first birth ( 27798627) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Household income (MTAG) ( 31844048) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Self-reported risk-taking behaviour ( 30271922 30181555) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)
Interacting Genes		28 interacting genes: BEND7 CCDC33 CEP70 CGGBP1 DOCK8 FOXP2 IHO1 INO80E KIFC3 LNX1 NKAP PHC2 PRKG1 RAB3IP RBM10 ROCK1 SAXO1 SRPK1 STAC3 THAP1 TLE5 TRIM41 TRIM54 ZBTB44 ZFP64 ZNF165 ZNF250 ZZZ3	13 interacting genes: CCNC CTBP1 CTBP2 FAM124A FOXP1 FOXP4 MAPK3 PIN1 RPIA SDCBP SP4 TLE5 TSACC
Entrez ID		220108	93986
HPRD ID		08704	05611
Ensembl ID		ENSG00000150510	ENSG00000128573
Uniprot IDs		Q86V42	B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2
PDB IDs			2A07 2AS5
Enriched GO Terms of Interacting Partners?
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